Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.

Auranofin is active against Histoplasma capsulatum and reduces the expression of virulence-related genes.

<h4>Background</h4>Auranofin is an approved anti-rheumatic drug that has a broad-range inhibitory action against several microorganisms, including human pathogenic fungi. The auranofin activity against Histoplasma capsulatum, the dimorphic fungus that causes histoplasmosis, has not been...

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Main Authors: Marcos de Abreu Almeida, Lilian Cristiane Baeza, Leandro B R Silva, Andréa Reis Bernardes-Engemann, Fernando Almeida-Silva, Rowena Alves Coelho, Iara Bastos de Andrade, Dario Corrêa-Junior, Susana Frases, Rosely Maria Zancopé-Oliveira, Alexandre Alanio, Carlos Pelleschi Taborda, Rodrigo Almeida-Paes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012586
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https://doi.org/10.1371/journal.pntd.0012586

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