Isocitrate Dehydrogenase-Wildtype Glioma Adapts Toward Mutant Phenotypes and Enhanced Therapy Sensitivity Under D-2-Hydroxyglutarate Exposure

Isocitrate Dehydrogenase-Wildtype Glioma Adapts Toward Mutant Phenotypes and Enhanced Therapy Sensitivity Under D-2-Hydroxyglutarate Exposure

<b>Background/Objectives</b>: Isocitrate dehydrogenase (<i>IDH</i>) mutations are hallmark features in subsets of gliomas, producing the oncometabolite D-2-hydroxyglutarate (2HG). Although <i>IDH</i> mutations are associated with better clinical outcomes, their re...

Full description

Saved in:
Bibliographic Details
Main Authors: Geraldine Rocha, Clara Francés-Gómez, Javier Megías, Lisandra Muñoz-Hidalgo, Pilar Casanova, Jose F. Haro-Estevez, Vicent Teruel-Martí, Daniel Monleón, Teresa San-Miguel
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
isocitrate dehydrogenase mutation
<i>IDH</i>
glioblastoma
astrocytoma
glioma
2-hydroxyglutarate
Online Access:https://www.mdpi.com/2227-9059/13/7/1584
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2227-9059/13/7/1584

Similar Items