Impact of ASXL1 Gene Alterations on Myelodysplastic Syndrome With Isolated 20q Deletion

Impact of ASXL1 Gene Alterations on Myelodysplastic Syndrome With Isolated 20q Deletion

ABSTRACT Background Isolated 20q deletion [del(20q)] is a recurrent favorable abnormality in myelodysplastic syndrome (MDS) and may cause deletion of the ASXL1 gene. Meanwhile, ASXL1 mutations are also common in individuals with MDS. This study aimed to describe the biological and clinical implicati...

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Main Authors: Yanan Chang, Linlin Liu, Chenghua Cui, Jiange He, Chengwen Li, Yujiao Jia, Ruixue Zhang, Wanyun Wu, Ji Zhou, Jigang Xiao, Zefeng Xu, Tiejun Qin, Qi Sun, Huijun Wang, Zhijian Xiao
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Medicine
Subjects:
20q deletion
ASXL1
copy number variant
mutation
myelodysplastic syndrome
Online Access:https://doi.org/10.1002/cam4.70747
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https://doi.org/10.1002/cam4.70747

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