BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression

BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression

The interaction between m6A-methylated RNA and chromatin modification remains largely unknown. We found that targeted inhibition of bromodomain-containing protein 4 (BRD4) by siRNA or its inhibitor (JQ1) significantly decreases mRNA m6A levels and suppresses the malignancy of breast cancer (BC) cell...

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Bibliographic Details
Main Authors: Haisheng Zhang, Linlin Lu, Cheng Yi, Tao Jiang, Yunqing Lu, Xianyuan Yang, Ke Zhong, Jiawang Zhou, Jiexin Li, Guoyou Xie, Zhuojia Chen, Zongpei Jiang, Gholamreza Asadikaram, Yanxi Peng, Dan Zhou, Hongsheng Wang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
BRD4
ALKBH5
ESPL1
TRIM21
RALY
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524004945
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