Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines

Combined cancer immunotherapy with lipid nanoparticle delivery of oligo-based cGAS-agonistic adjuvant and peptide or mRNA vaccines

Therapeutic vaccines are promising for cancer immunotherapy in combination with immune checkpoint blockade (ICB). Though lipid nanoparticles (LNPs) hold great potential to deliver cancer therapeutic vaccines, LNPs delivering peptide or mRNA vaccines often induce suboptimal T cell responses. Type I i...

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Bibliographic Details
Main Authors: Shurong Zhou, Yuqing Liang, Yu Hao, Qiyan Wang, You Xu, Ting Su, Furong Cheng, Guizhi Zhu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
oligonucleotide adjuvant
mRNA vaccine
cGAS-STING
lipid nanoparticle
vaccine codelivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001775
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http://www.sciencedirect.com/science/article/pii/S2162253125001775

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