TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation

TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation

Abstract Background Tumor dissemination is a life-threatening event which confers to most cancer-related deaths with limited effective therapeutic option. TNFα-induced protein 2 (TNFAIP2) reveals pro-metastasis potential in several cancers. However, its definite role and underlying mechanism in oral...

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Bibliographic Details
Main Authors: Teng Xu, Yaning Wang, Zechen Zhao, Jinsong Wang, Zhenyuan Zhao, Yuemei Yang, Xiaomeng Song, Qingguo Lai
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
OSCC
TNFAIP2
KEAP1
NF-κB signaling
Nanoscale delivery systems
Online Access:https://doi.org/10.1186/s12964-025-02077-3
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https://doi.org/10.1186/s12964-025-02077-3

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