Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers

Discovery of Drugs Targeting Mutant p53 and Progress in Nano-Enabled Therapeutic Strategy for p53-Mutated Cancers

Mutations in the p53 gene are frequently observed in various cancers, prompting the initiation of efforts to restore p53 function as a therapeutic approach several decades ago. Nevertheless, only a limited number of drug development initiatives have progressed to late-stage clinical trials, and to d...

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Bibliographic Details
Main Authors: Na Zhang, Zhiyuan Jing, Jie Song, Qiyue Liang, Yuxue Xu, Zhaowei Xu, Longping Wen, Pengfei Wei
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
mutant p53
mutant p53 reactivation
protein stability
nanodelivery
Online Access:https://www.mdpi.com/2218-273X/15/6/763
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