Folate-based binuclear Mn(II) chelates with 2,2’-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells

Folate-based binuclear Mn(II) chelates with 2,2’-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells

Abstract Researchers have shown significant interest in the chemistry of mixed ligand transition metal chelates due to their diverse applications and bonding features. Herein, we have reported the synthesis of two new binuclear Mn(II) chelates with the composition of [Mn2(FA)(Bpy)2(H2O)2Cl2].7H2O (C...

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Bibliographic Details
Main Authors: Mona S. Ragab, Marwa H. Soliman, Marwa M. Sharaky, Abdelrahman Saad, Mohamed R. Shehata, Mohamed M. Shoukry, Mohamed A. Ragheb
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
New binuclear Mn(II) chelates
DFT computations
Anti-apoptotic proteins
Positive folate receptor
Cytotoxicity
And HCT116 cell arrest at S- phase.
Online Access:https://doi.org/10.1038/s41598-025-12251-9
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https://doi.org/10.1038/s41598-025-12251-9

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