Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotype

Abstract Anxiety and depression are common in Parkinson’s disease (PD), affecting quality of life. Aggregates of α-synuclein (α-Syn) are found in serotonergic (5-HT) raphe nuclei early in the disease, but their relationship to brain changes is unclear. We investigated synaptic plasticity, neuronal a...

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Main Authors: Lluis Miquel-Rio, Judith Jericó-Escolar, Unai Sarriés-Serrano, Claudia Yanes-Castilla, María Torres-López, Uxia Argibay, Verónica Paz, Carme Casal, Emma Muñoz-Moreno, Xavier López-Gil, Analia Bortolozzi
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01073-1
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https://doi.org/10.1038/s41531-025-01073-1

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