Amniotic membrane promotes doxorubicin potency by suppressing SH-SY5Y neuroblastoma cell angiogenesis

Amniotic membrane promotes doxorubicin potency by suppressing SH-SY5Y neuroblastoma cell angiogenesis

Abstract Background Doxorubicin (DOX) remains a mainstay for neuroblastoma (NB) treatment, but side effects hamper efficacy. We previously showed that DOX induces SH-SY5Y NB cell angiogenesis via the PHD-2/HIF-1α axis. Adjuvant therapies offer a promising avenue to improved outcomes. Human amniotic...

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Main Authors: Ahmed M. Abou-Shanab, Shaimaa Shouman, Alaa E. Hussein, Ola A. Gaser, Shireen Magdy, Eman Ashraf, Radwa Ayman Salah, Omaima Idris, Nagwa El-Badri
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Neuroblastoma
Amniotic membrane extract
Doxorubicin
NB angiogenesis
Mitochondrial metabolism
Online Access:https://doi.org/10.1186/s12885-025-14442-z
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https://doi.org/10.1186/s12885-025-14442-z

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