YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression

YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression

Abstract Background Neuroblastoma (NB), the most prevalent solid tumor in children, arises from sympathetic nervous system and accounts for 15% of pediatric cancer mortality. This malignancy exhibits substantial genetic and clinical heterogeneity, thus complicating treatment strategies. Poly(ADP-rib...

Full description

Saved in:
Bibliographic Details
Main Authors: Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Translational Medicine
Subjects:
Neuroblastoma
Poly(ADP-ribose) polymerase 1
Yin Yang 1
Non-POU domain containing octamer binding protein
Transcriptional regulation
Protein PARylation
Online Access:https://doi.org/10.1186/s12967-024-05956-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-024-05956-4

Similar Items