Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models

Abstract Regulatory T (Treg)-based cell therapy holds promise for autoimmune and inflammatory diseases, yet challenges remain regarding the functional stability and persistence of transferred Tregs. Here we engineer Tregs to express a partial agonist form of IL-2 (IL-2pa) to enhance persistence whil...

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Main Authors: Janie Robert, Manon Feuillolay, María de Temple-Llavero, Reginald Florian Akossi, Vanessa Mhanna, Mustapha Cheraï, Gwladys Fourcade, Frédéric Charlotte, Nicolas Tchitchek, Tian Mi, Benjamin Youngblood, Thomas Vazquez, Michelle Rosenzwajg, David Klatzmann
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60082-z
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https://doi.org/10.1038/s41467-025-60082-z

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