The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain
Objectives. Diagnosis of pediatric patients presenting to the Emergency Department with acute abdominal pain is not always easy. The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diag...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2018/3296535 |
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| _version_ | 1832548806907920384 |
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| author | Fatma Sarac Sevgi Buyukbese Sarsu Selman Yeniocak Kamil Sahin Esma Yucetas Dogan Yildirim Macit Koldas Ozlem Uzun |
| author_facet | Fatma Sarac Sevgi Buyukbese Sarsu Selman Yeniocak Kamil Sahin Esma Yucetas Dogan Yildirim Macit Koldas Ozlem Uzun |
| author_sort | Fatma Sarac |
| collection | DOAJ |
| description | Objectives. Diagnosis of pediatric patients presenting to the Emergency Department with acute abdominal pain is not always easy. The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diagnosis of pediatric patients with acute abdominal pain. Methods. 162 subjects consenting to participate, including 112 patients presenting to the Pediatric Emergency and Pediatric Surgery clinics with acute abdominal pain and 50 controls, were enrolled in the study. Blood was collected from all patients following initial examination for irisin, WBC, and CRP investigation. Results. Mean irisin levels in cases of acute appendicitis (AA) and perforated appendicitis (PA) were statistically significantly higher compared to nonspecific abdominal pains and the control group. No statistically significant difference was observed in irisin levels between AA and PA cases. WBC and CRP levels were also significantly higher in cases of AA and PA compared to nonspecific abdominal pains. Conclusions. Differential diagnosis of acute abdominal pains in children and deciding on surgery are a difficult and complex process. Our study shows that irisin can be a useful biomarker in differentiating AA and PA from other acute abdominal pains in children. |
| format | Article |
| id | doaj-art-32ac46a0b8dd4ce1b9eb9c86498d4fe3 |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-32ac46a0b8dd4ce1b9eb9c86498d4fe32025-02-03T06:12:56ZengWileyEmergency Medicine International2090-28402090-28592018-01-01201810.1155/2018/32965353296535The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal PainFatma Sarac0Sevgi Buyukbese Sarsu1Selman Yeniocak2Kamil Sahin3Esma Yucetas4Dogan Yildirim5Macit Koldas6Ozlem Uzun7Department of Pediatric Surgery, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of Pediatric Surgery, Cengiz Gökcek Obstetrics and Children’s Hospital, Gaziantep, TurkeyDepartment of Emergency Medicine, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of Pediatrics, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of Biochemistry, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of General Surgery, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of Biochemistry, Haseki Research and Education Hospital, Istanbul, TurkeyDepartment of Emergency Medicine, Bagcilar Research and Education Hospital, Istanbul, TurkeyObjectives. Diagnosis of pediatric patients presenting to the Emergency Department with acute abdominal pain is not always easy. The purpose of this study was to investigate the effectiveness of irisin, a peptide hormone with reactivity shown in the appendix and neutrophils, in the differential diagnosis of pediatric patients with acute abdominal pain. Methods. 162 subjects consenting to participate, including 112 patients presenting to the Pediatric Emergency and Pediatric Surgery clinics with acute abdominal pain and 50 controls, were enrolled in the study. Blood was collected from all patients following initial examination for irisin, WBC, and CRP investigation. Results. Mean irisin levels in cases of acute appendicitis (AA) and perforated appendicitis (PA) were statistically significantly higher compared to nonspecific abdominal pains and the control group. No statistically significant difference was observed in irisin levels between AA and PA cases. WBC and CRP levels were also significantly higher in cases of AA and PA compared to nonspecific abdominal pains. Conclusions. Differential diagnosis of acute abdominal pains in children and deciding on surgery are a difficult and complex process. Our study shows that irisin can be a useful biomarker in differentiating AA and PA from other acute abdominal pains in children.http://dx.doi.org/10.1155/2018/3296535 |
| spellingShingle | Fatma Sarac Sevgi Buyukbese Sarsu Selman Yeniocak Kamil Sahin Esma Yucetas Dogan Yildirim Macit Koldas Ozlem Uzun The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain Emergency Medicine International |
| title | The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain |
| title_full | The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain |
| title_fullStr | The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain |
| title_full_unstemmed | The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain |
| title_short | The Diagnostic Value of Irisin in Pediatric Patients with Acute Abdominal Pain |
| title_sort | diagnostic value of irisin in pediatric patients with acute abdominal pain |
| url | http://dx.doi.org/10.1155/2018/3296535 |
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