Polarity protein Par6 facilitates the processive phosphorylation of Lgl via a dynamic interaction with aPKC

Abstract Polarity along an apical-basal axis is essential for epithelial cell shape and function. The atypical protein Kinase-C (aPKC) and its regulatory partner Par6 form a complex that is essential for polarization, a primary function of which is to phosphorylate the Lethal giant larvae (Lgl) prot...

Full description

Saved in:
Bibliographic Details
Main Authors: Lior Almagor, William I. Weis
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08401-4
Tags: Add Tag
No Tags, Be the first to tag this record!