Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy

Dimethyl fumarate modulates M1/M2 macrophage polarization to ameliorate periodontal destruction by increasing TUFM-mediated mitophagy

Abstract Periodontitis is a common oral disease characterized by progressive alveolar bone resorption and inflammation of the periodontal tissues. Dimethyl fumarate (DMF) has been used in the treatment of various immune-inflammatory diseases due to its excellent anti-inflammatory and antioxidant fun...

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Main Authors: Liang Chen, Pengxiao Hu, Xinhua Hong, Bin Li, Yifan Ping, ShuoMin Chen, Tianle Jiang, Haofu Jiang, Yixin Mao, Yang Chen, Zhongchen Song, Zhou Ye, Xiaoyu Sun, Shufan Zhao, Shengbin Huang
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-025-00360-0
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https://doi.org/10.1038/s41368-025-00360-0

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