Hepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis

Hepatic AKAP1 deficiency exacerbates diet-induced MASLD by enhancing GPAT1-mediated lysophosphatidic acid synthesis

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), closely associated with obesity, can progress to metabolic dysfunction-associated steatohepatitis when the liver undergoes overt inflammatory damage. A-kinase anchoring protein 1 (AKAP1) has been shown to control lipid accumu...

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Main Authors: Linjie He, Xiaojuan She, Lifei Guo, Mingshu Gao, Shuangbin Wang, Zhenxing Lu, Haitao Guo, Renlong Li, Yongzhan Nie, Jinliang Xing, Lele Ji
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58790-7
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https://doi.org/10.1038/s41467-025-58790-7

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