Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4/MyD88/NF-κB/NLRP3 pathway

Shen Shuai II Recipe alleviates renal fibrosis in chronic kidney disease by improving of hypoxia and inhibition of TLR4/MyD88/NF-κB/NLRP3 pathway

Objectives To investigate the anti-fibrotic mechanisms of Shen Shuai II Recipe (SSR) in chronic kidney disease (CKD), focusing on its modulation of hypoxia-associated inflammatory pathways and the TLR4/MyD88/NF-κB/NLRP3 axisMethods A 5/6 nephrectomy-induced chronic renal failure (CRF) rat model and...

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Bibliographic Details
Main Authors: Yuan Zhou, Liang Zhou, Meng Wang, Lin Xu, Tingting Li, Chen Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
Shen Shuai II Recipe (SSR)
hypoxia
renal interstitial fibrosis
inflammation
TLR4/MyD88/NF-κB
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2502875
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2502875

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