NSUN2 knockdown ameliorates hepatic glucose and lipid metabolism disorders in type 2 diabetes mellitus through the Inhibition of ACSL6 m5C methylation

Abstract Background Hyperglycemia and dyslipidemia characterize type 2 diabetes mellitus (T2DM). The impact of 5-methylcytosine (m5C) on liver glucose and lipid regulation in T2DM is unclear. In this study, the regulation of liver glucose and lipid metabolism by m5C methylation in a T2DM model was i...

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Bibliographic Details
Main Authors: Xianshu Jiang, Xuelan Cheng, Qiu Wan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Lipids in Health and Disease
Subjects:
Online Access:https://doi.org/10.1186/s12944-025-02652-0
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