AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization

AXL promotes inflammatory breast cancer progression by regulating immunosuppressive macrophage polarization

Abstract Background Tumor-associated macrophages (TAMs) are key promoters of inflammatory breast cancer (IBC), the most aggressive form of breast cancer. The receptor tyrosine kinase AXL is highly expressed in various cancer types, including IBC, but its role in TAMs remains unexplored. Methods We e...

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Main Authors: Lan T. H. Phi, Yating Cheng, Yohei Funakoshi, Francois Bertucci, Pascal Finetti, Steven J. Van Laere, Fang Zou, James P. Long, Suguru Ogata, Savitri Krishnamurthy, James M. Reuben, Jason M. Foulks, Steven L. Warner, Jennifer M. Rosenbluth, Anil K. Sood, Debu Tripathy, Naoto T. Ueno, Xiaoping Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Online Access:https://doi.org/10.1186/s13058-025-02015-8
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https://doi.org/10.1186/s13058-025-02015-8

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