Behavioural, psychiatric, and cognitive phenotypes associated with numbers of repeats of the FRAXE allele on the FMR2 gene [version 2; peer review: 1 approved, 3 approved with reservations]

Behavioural, psychiatric, and cognitive phenotypes associated with numbers of repeats of the FRAXE allele on the FMR2 gene [version 2; peer review: 1 approved, 3 approved with reservations]

Background The FRAXE site on the X-chromosome has a variable number of trinucleotide repeats. The rare condition Fragile XE has >200 repeats, but most X chromosomes have <60 such repeats, with evidence of a bimodal distribution. It is known that when the number of repeats is <60, the repeat...

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Main Authors: Jean Golding, Sarah Ennis, Marcus E. Pembrey, Yasmin Iles-Caven, Matthew Suderman, Steven Gregory, Susan M. Ring, Rosie Clark
Format: Article
Language:English
Published: Wellcome 2025-04-01
Series:Wellcome Open Research
Subjects:
ALSPAC
FRAXE
FMR2
psychosis
substance addiction
smoking
eng
Online Access:https://wellcomeopenresearch.org/articles/9-238/v2
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https://wellcomeopenresearch.org/articles/9-238/v2

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