Knockout of glycerol metabolic pathways enables efficient mycolicibacterial phytosterol conversion using glycerol as cosovlent

Abstract Mycobacterial phytosterol conversion naturally occurs within a vegetable oil environment, a process that has been widely adopted in water‒oil two-phase fermentation to produce active pharmaceutical intermediates of steroids. The use of hydroxypropyl-β-CD (HP-β-CD) as a potential replacement...

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Bibliographic Details
Main Authors: Shikui Song, Ye Wang, Jinpeng Yu, Qianqian Ma, Xiyao Cheng, Baoguo Zhang, Zhengding Su
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Applied Microbiology and Biotechnology
Subjects:
Online Access:https://doi.org/10.1007/s00253-024-13360-7
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