Global and regional genetic association analysis of ulcerative colitis and type 2 diabetes mellitus and causal validation analysis of two-sample two-way Mendelian randomization

Global and regional genetic association analysis of ulcerative colitis and type 2 diabetes mellitus and causal validation analysis of two-sample two-way Mendelian randomization

BackgroundClinical co-occurrence of UC (Ulcerative Colitis) and T2DM (Type 2 Diabetes Mellitus) is observed. The aim of this study is to investigate the potential causal relationship between Ulcerative Colitis (UC) and Type 2 Diabetes Mellitus (T2DM) using LDSC and LAVA analysis, followed by genetic...

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Main Authors: Yan-zhi Hu, Zhe Chen, Ming-han Zhou, Zhen-yu Zhao, Xiao-yan Wang, Jun Huang, Xin-tian Li, Juan-ni Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
UC
T2DM
Mendelian randomization
LDSC analysis
LAVA analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375915/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1375915/full

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