A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A

A new treatment for canine B-cell lymphoma based on a recombinant single-domain antibody immunotoxin derived from Pseudomonas aeruginosa exotoxin A

Canine lymphoma is one of the most common and aggressive hematopoietic tumors in dogs. Despite recent advances in veterinary cancer treatments, the lack of specificity, side effects, and resistance to conventional chemotherapies has opened an urgent need to develop more targeted and safe therapeutic...

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Main Authors: Ana S. André, Joana N. R. Dias, Isa Moutinho, Joana Loureiro, Ana Leonardo, Sara Nogueira, Rafaela P. Marimon, Pedro Bule, Jorge Correia, Rui Malhó, Lurdes Gano, João D. G. Correia, Solange Gil, João Gonçalves, Ira Pastan, Luís Tavares, Frederico Aires-da-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Veterinary Science
Subjects:
canine B-cell lymphoma
immunotoxin therapy
recombinant single-domain antibody
comparative oncology
targeted cancer therapeutic
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1491934/full
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https://www.frontiersin.org/articles/10.3389/fvets.2025.1491934/full

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