Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation
Plasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. Alongside a strong correlation with HIV, PBL can manifest in immunocompromised HIV-negative patients. A rare case of PBL in an immunocompetent and otherwise healthy child presente...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/4353830 |
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| author | Ali Mala Yameena Noman Khan Akbar Ahmed Naema Khayyam Kanwal Aftab |
| author_facet | Ali Mala Yameena Noman Khan Akbar Ahmed Naema Khayyam Kanwal Aftab |
| author_sort | Ali Mala |
| collection | DOAJ |
| description | Plasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. Alongside a strong correlation with HIV, PBL can manifest in immunocompromised HIV-negative patients. A rare case of PBL in an immunocompetent and otherwise healthy child presented to Indus Hospital & Health Network (IHHN), Karachi, Pakistan. The patient had complaints of swelling and pain in the right leg and was referred from a city in Interior Sindh. Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony fragments. Large, monomorphic, multinucleated neoplastic cells containing abundant cytoplasm and scattered pleomorphic cells were also noted, leading to the diagnosis of tibial plasmablastic lymphoma. A FAB/LMB96 group C chemotherapy regimen for aggressive and high-risk cancer was administered with a marked improvement in clinical symptoms. |
| format | Article |
| id | doaj-art-3220bcba4ba44988a4dcc5a59ac8952e |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-3220bcba4ba44988a4dcc5a59ac8952e2025-02-03T01:23:36ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/4353830Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral LocalisationAli Mala0Yameena Noman Khan1Akbar Ahmed2Naema Khayyam3Kanwal Aftab4Indus Hospital and Health NetworkIndus Hospital and Health NetworkIndus Hospital and Health NetworkIndus Hospital and Health NetworkIndus Hospital and Health NetworkPlasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. Alongside a strong correlation with HIV, PBL can manifest in immunocompromised HIV-negative patients. A rare case of PBL in an immunocompetent and otherwise healthy child presented to Indus Hospital & Health Network (IHHN), Karachi, Pakistan. The patient had complaints of swelling and pain in the right leg and was referred from a city in Interior Sindh. Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony fragments. Large, monomorphic, multinucleated neoplastic cells containing abundant cytoplasm and scattered pleomorphic cells were also noted, leading to the diagnosis of tibial plasmablastic lymphoma. A FAB/LMB96 group C chemotherapy regimen for aggressive and high-risk cancer was administered with a marked improvement in clinical symptoms.http://dx.doi.org/10.1155/2022/4353830 |
| spellingShingle | Ali Mala Yameena Noman Khan Akbar Ahmed Naema Khayyam Kanwal Aftab Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation Case Reports in Hematology |
| title | Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation |
| title_full | Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation |
| title_fullStr | Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation |
| title_full_unstemmed | Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation |
| title_short | Tibial Plasmablastic Lymphoma in a HIV-Negative Child: A Novel Extraoral Localisation |
| title_sort | tibial plasmablastic lymphoma in a hiv negative child a novel extraoral localisation |
| url | http://dx.doi.org/10.1155/2022/4353830 |
| work_keys_str_mv | AT alimala tibialplasmablasticlymphomainahivnegativechildanovelextraorallocalisation AT yameenanomankhan tibialplasmablasticlymphomainahivnegativechildanovelextraorallocalisation AT akbarahmed tibialplasmablasticlymphomainahivnegativechildanovelextraorallocalisation AT naemakhayyam tibialplasmablasticlymphomainahivnegativechildanovelextraorallocalisation AT kanwalaftab tibialplasmablasticlymphomainahivnegativechildanovelextraorallocalisation |