Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups

Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups

Abstract Polygenic risk scores (PRS) are useful for assessing disease risk; however, knowledge about their effectiveness among Asian and other populations is limited. This study aimed to compare the classification accuracy of PRSs for type 2 diabetes (T2D-PRS) developed from different ancestry group...

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Main Authors: Takuma Furukawa, Megumi Hara, Yuichiro Nishida, Keitaro Tanaka, Chisato Shimanoe, Chiharu Iwasaka, Jun Otonari, Hiroaki Ikezaki, Mako Nagayoshi, Takashi Tamura, Yudai Tamada, Rieko Okada, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Takahiro Otani, Isao Watanabe, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Aya Kadota, Masashi Ishizu, Takeshi Watanabe, Masahiro Nakatochi, Yukihide Momozawa, Kenji Wakai, Keitaro Matsuo, for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-025-00059-0
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https://doi.org/10.1038/s44324-025-00059-0

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