Bioinformatics analysis of intrinsic drivers of immune dysregulation in multiple myeloma to elucidate immune phenotypes and discover prognostic gene signatures

Bioinformatics analysis of intrinsic drivers of immune dysregulation in multiple myeloma to elucidate immune phenotypes and discover prognostic gene signatures

Abstract Multiple myeloma (MM) progression is driven by immune dysregulation within the tumor microenvironment (TME). However, myeloma-intrinsic mechanisms underlying immune dysfunction remain poorly defined, and current immunotherapies show limited efficacy. Using RNA-seq data from 859 MM patients...

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Bibliographic Details
Main Authors: Chuan-Feng Fang, Yan Li, Chun Yang, Hua Fang, Chen Li
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Multiple myeloma
Immune dysfunction
Immunosuppress
Tumor microenvironment
Prognostic signature
Online Access:https://doi.org/10.1038/s41598-025-00074-7
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https://doi.org/10.1038/s41598-025-00074-7

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