NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells

NKG2D triggering hampers DNAM-1-mediated signaling in human NK cells

IntroductionNatural Killer (NK) cells are cytotoxic innate lymphocytes able to detect transformed cells through the balanced action of inhibitory and activating receptors. NKG2D is one of the main activating receptors involved in tumor surveillance thanks to its ability to recognize stress-induced l...

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Main Authors: Caterina Marangio, Nadia Domenica Milito, Erisa Putro, Alessia Carnevale, Cristina Capuano, Alessandra Zingoni, Marco Cippitelli, Angela Santoni, Rossella Paolini, Rosa Molfetta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
innate immunity
NK cells
NK cell receptors
functional exhaustion
signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575059/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575059/full

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