MBX-102/JNJ39659100, a Novel Non-TZD Selective Partial PPAR-𝛾 Agonist Lowers Triglyceride Independently of PPAR-𝛼 Activation

MBX-102/JNJ39659100, a Novel Non-TZD Selective Partial PPAR-𝛾 Agonist Lowers Triglyceride Independently of PPAR-𝛼 Activation

MBX-102/JNJ-39659100 (MBX-102) is a selective, partial PPAR-𝛾 agonist that lowers glucose in the absence of some of the side effects, such as weight gain and edema, that are observed with the TZDs. Interestingly MBX-102 also displays pronounced triglyceride lowering in preclinical rodent models and...

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Bibliographic Details
Main Authors: Apurva Chandalia, Holly J. Clarke, L. Edward Clemens, Bindu Pandey, Vic Vicena, Paul Lee, Brian E. Lavan, Francine M. Gregoire
Format: Article
Language:English
Published: Wiley 2009-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2009/706852
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