Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer

Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer

Abstract Hybrid molecules can be engineered to target tumors by merging drugs with the same or distinct mechanisms of action. The coexistence of multiple pharmacologically active entities within the cancer cell enhances the therapeutic efficacy of the hybrid molecule compared to single-target inhibi...

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Bibliographic Details
Main Authors: Khanittha Laowichuwakonnukul, Boonchoy Soontornworajit, Jiraporn Arunpanichlert, Pichayanoot Rotkrua
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
AS1411 aptamer
Colorectal cancer
Drug carrier
MicroRNA-143
Online Access:https://doi.org/10.1038/s41598-025-94159-y
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https://doi.org/10.1038/s41598-025-94159-y

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