PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Abstract Pancreatic stellate cells (PSCs) contribute to pancreatic ductal adenocarcinoma (PDAC) progression and therapeutic resistance, yet their detailed functions remain unclear. This study combined RNA sequencing and assay for transposase‐accessible chromatin using sequencing (ATAC‐seq) on sorted...

Full description

Saved in:
Bibliographic Details
Main Authors: Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
activation, heterogeneity
immunotherapy resistance
pancreatic stellate cells (PSCs); PLXDC1+ tumor‐associated PSCs
single‐cell and spatial transcriptomes
Online Access:https://doi.org/10.1002/advs.202415756
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202415756

Similar Items