Transcellular chaperone signaling is an intercellular stress-response distinct from the HSF-1-mediated heat shock response.

Organismal proteostasis is maintained by intercellular signaling processes including cell nonautonomous stress responses such as transcellular chaperone signaling (TCS). When TCS is activated upon tissue-specific knockdown of hsp-90 in the Caenorhabditis elegans intestine, heat-inducible hsp-70 is i...

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Bibliographic Details
Main Authors: Jay Miles, Sarah Townend, Dovilė Milonaitytė, William Smith, Francesca Hodge, David R Westhead, Patricija van Oosten-Hawle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001605&type=printable
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