ATP6AP1 drives pyroptosis-mediated immune evasion in hepatocellular carcinoma: a machine learning-guided therapeutic target
Abstract Background Hepatocellular carcinoma (HCC) remains a major therapeutic challenge due to its immunosuppressive tumor microenvironment (TME) and resistance to immune checkpoint inhibitors (ICIs). Pyroptosis is a form of cell death with complex dual functions in tumor immunity. However, the pre...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-04-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-02426-1 |
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