Prophages divert Staphylococcus aureus defenses against host lipids

Prophages divert Staphylococcus aureus defenses against host lipids

Phages are ubiquitous in bacteria, including clinical Staphylococcus aureus, where Sfi 21/Sa3 phages often integrate into the hlb gene, which encodes Hlb sphingomyelinase. This integration acts as a rapid regulatory switch for Hlb production. Our findings suggest that Sfi 21/Sa3 prophages and Hlb ac...

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Bibliographic Details
Main Authors: Biyang Zhou, Amit Pathania, Deepak Pant, David Halpern, Philippe Gaudu, Patrick Trieu-Cuot, Andressa Dias-Leao, Charlotte Pagot, Audrey Solgadi, Alexandra Gruss, Karine Gloux
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Lipid Research
Subjects:
fatty acid transport
phospholipases C
triglycerides
sphingolipids
lipolysis and fatty acid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524001986
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