High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy–lysosomal pathway in endometrial cancer

High glucose levels promote glycolysis and cholesterol synthesis via ERRα and suppress the autophagy–lysosomal pathway in endometrial cancer

Abstract Endometrial cancer (EC) patients with Diabetes Mellitus (DM) always have a poor prognosis. Estrogen-related receptor α (ERRα) is known as the metabolic-related prognostic factor for EC. However, the mechanism linking glycolipid metabolism dysfunction mediated by ERRα to poor prognosis of EC...

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Main Authors: Xiaodan Mao, Lixiang Huang, Xianhua Liu, Xite Lin, Qibin Wu, Xinrui Wang, Yuan Ren, Jincheng Ma, Maotong Zhang, Yao Lin, Damian J. Ralser, Alexander Mustea, Gang Chen, Pengming Sun
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07499-y
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https://doi.org/10.1038/s41419-025-07499-y

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