RNA helicase maheshvara interacts with TDP-43 and exacerbates neurodegeneration in Drosophila model of amyotrophic lateral sclerosis

RNA helicase maheshvara interacts with TDP-43 and exacerbates neurodegeneration in Drosophila model of amyotrophic lateral sclerosis

Drosophila maheshvara (mahe) encodes a conserved DEAD box RNA helicase that regulates various important signaling pathways like Notch and JAK/STAT, pathways that have been functionally implicated in neuronal development. In order to identify novel modulators of mahe as well as to unravel its role in...

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Bibliographic Details
Main Authors: Pranjali Pandey, Rituparna Das, Harshita Yadav, Ashim Mukherjee, Mousumi Mutsuddi
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
Dead box RNA helicase
Amyotrophic lateral sclerosis
TDP-43
Autophagy
FMRP
Futsch
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002529
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