Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying a bispecific T cell engager against hepatocellular carcinoma

Systemic administration of mesenchymal stem cells loaded with a novel oncolytic adenovirus carrying a bispecific T cell engager against hepatocellular carcinoma

We previously established a hepatocellular carcinoma (HCC) targeting system of conditionally replicative adenovirus (CRAd) delivered by human umbilical cord-derived mesenchymal stem cells (HUMSCs). However, this system needed to be developed further to enhance the antitumor effect and overcome the l...

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Bibliographic Details
Main Authors: Xiangfei Yuan, Yang Lu, Yuanyuan Yang, Wencong Tian, Dongmei Fan, Ruoqi Liu, Xiaomin Lei, Yafei Xia, Lei Yang, Shu Yan, Dongsheng Xiong
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
AFP
BiTE
Crad
HCC
hepatic differentiation
HUMSC
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2219544
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https://www.tandfonline.com/doi/10.1080/2162402X.2023.2219544

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