Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

Effect of the frequently used antiepileptic drugs carbamazepine, gabapentin, and pregabalin on the pharmacokinetics of edoxaban and other oral factor xa inhibitors in healthy volunteers

PurposePregabalin, gabapentin, and carbamazepine, a potent inducer of cytochrome P450 (CYP) 3A4 and P-glycoprotein, are frequently used antiepileptic drugs that are often administered together with factor Xa inhibitors (FXaI). We aimed to investigate whether potentially clinically relevant drug-drug...

Full description

Saved in:
Bibliographic Details
Main Authors: Alexander Lenard, Simon A. Hermann, Felicitas Stoll, Juergen Burhenne, Kathrin I. Foerster, David Czock, Gerd Mikus, Andreas D. Meid, Walter E. Haefeli, Antje Blank
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
factor Xa inhibitors
edoxaban
carbamazepine
gabapentin
pregabalin
drug-drug interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1542063/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2025.1542063/full

Similar Items