Combining biosensor and metabolic network optimization strategies for enhanced l-threonine production in Escherichia coli

Combining biosensor and metabolic network optimization strategies for enhanced l-threonine production in Escherichia coli

Abstract l-threonine is an integral nutrient for mammals, often used in animal feeds to enhance growth and reduce breeding costs. Developing l-threonine engineered strains that meet industrial production specifications has significant economic value. Here, we developed a biosensor that monitors l-th...

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Bibliographic Details
Main Authors: Zhenqiang Zhao, Rongshuai Zhu, Xuanping Shi, Fengyu Yang, Meijuan Xu, Minglong Shao, Rongzhen Zhang, Youxi Zhao, Jiajia You, Zhiming Rao
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
l-Threonine biosensor
Directed evolution
High-throughput
Multi-omics analysis
In silico simulation
Online Access:https://doi.org/10.1186/s13068-025-02640-7
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https://doi.org/10.1186/s13068-025-02640-7

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