Effect of the reverse transcriptase inhibitor efavirenz on 5-azacytidine-induced LINE1 long interspersed repeat expression and genetic instability in acute myeloid leukemia cells

Effect of the reverse transcriptase inhibitor efavirenz on 5-azacytidine-induced LINE1 long interspersed repeat expression and genetic instability in acute myeloid leukemia cells

Introduction. The use of hypomethylating agents in the treatment of acute myeloid leukemia has increased overall patient survival by 12 %. However, alongside their potent antitumor effect, hypomethylating agents negatively impact genome stability due to the transposition of activated LINE1 elements,...

Full description

Saved in:
Bibliographic Details
Main Authors: Kh. M. Magomedova, I. A. Antonova, M. S. Strelkov, V. A. Nurtdinova, V. T. Cheshchevik, K. I. Kirsanov, G. A. Belitsky, M. G. Yakubovskaya, O. A. Vlasova
Format: Article
Language:Russian
Published: ABV-press 2025-06-01
Series:Успехи молекулярной онкологии
Subjects:
acute myeloid leukemia
hypomethylating agent
retroviral reverse transcriptase inhibitor
long interspersed repeats line1
5-azacytidine
efavirenz
Online Access:https://umo.abvpress.ru/jour/article/view/788
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://umo.abvpress.ru/jour/article/view/788

Similar Items