Unlocking the potential of trifluoromethyl pyrrole derivatives in chronic wounds management: rapid synthesis, structural insights, and potent antimicrobial activity

Unlocking the potential of trifluoromethyl pyrrole derivatives in chronic wounds management: rapid synthesis, structural insights, and potent antimicrobial activity

Using a one-pot, three-component approach, we synthesised 25 dihydropyrrol-2-one and two 5-oxo-2,5-dihydrofuran compounds, each featuring two trifluoromethyl groups. This method emphasises timeliness and cost-effectiveness, crucial in drug development. Structural verification was conducted using NMR...

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Bibliographic Details
Main Authors: Rafaela Vrabie, Mariana Pinteala, Cristina M. Al-Matarneh, Ioana C. Marinas, Alina Nicolescu, Sergiu Shova, Mihaela Silion, Mădălina-Diana Gaboreanu, Mariana C. Chifiriuc
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Dihydro-pyrrol-2-one
Doebner-type synthesis
antimicrobial activity
trifluoromethyl
chronic wounds
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2025.2513406
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https://www.tandfonline.com/doi/10.1080/14756366.2025.2513406

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