Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses.

Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses.

Recent studies have shown high usage of the IGHV1-69 germline immunoglobulin gene for influenza hemagglutinin stem-directed broadly-neutralizing antibodies (HV1-69-sBnAbs). Here we show that a major structural solution for these HV1-69-sBnAbs is achieved through a critical triad comprising two CDR-H...

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Main Authors: Yuval Avnir, Aimee S Tallarico, Quan Zhu, Andrew S Bennett, Gene Connelly, Jared Sheehan, Jianhua Sui, Amr Fahmy, Chiung-yu Huang, Greg Cadwell, Laurie A Bankston, Andrew T McGuire, Leonidas Stamatatos, Gerhard Wagner, Robert C Liddington, Wayne A Marasco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004103&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004103&type=printable

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