IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells

IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells

Abstract Malaria infection elicits both protective and pathogenic immune responses, and IL‐27 is a critical cytokine that regulate effector responses during infection. Here, we identified a critical window of CD4+ T cell responses that is targeted by IL‐27. Neutralization of IL‐27 during acute infec...

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Main Authors: Maria Lourdes Macalinao, Shin‐Ichi Inoue, Sanjaadorj Tsogtsaikhan, Hirotaka Matsumoto, Ganchimeg Bayarsaikhan, Jiun‐Yu Jian, Kazumi Kimura, Yoshiaki Yasumizu, Tsuyoshi Inoue, Hiroki Yoshida, Julius Hafalla, Daisuke Kimura, Katsuyuki Yui
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
CD4+ T cells
IL‐27
immunological memory
malaria
Th1
Online Access:https://doi.org/10.15252/emmm.202317713
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https://doi.org/10.15252/emmm.202317713

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