Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist

Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist

As T and NK cell exhaustion is attributed to increased expression of immune checkpoints and decreased production of proliferative cytokines by these cells, immune checkpoint-targeted delivery of proliferative cytokines might induce robust and sustained antitumor immune responses. Here, the expressio...

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Bibliographic Details
Main Authors: Jie Chen, Enhui Ren, Ze Tao, Hongyu Lu, Yunchuan Huang, Jing Li, Yuzhe Chen, Zhuo Chen, Tianshan She, Hao Yang, Hong Zhu, Xiaofeng Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
Immunotherapy
immune checkpoint inhibitor
IL-2R agonist
T and NK cell exhaustion
IgG-binding domain
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2482195
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https://www.tandfonline.com/doi/10.1080/10717544.2025.2482195

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