COMPOUNDS BASED ON TRIS(1-ALKYLINDOL-3-YL)METHAN FOR OVERCOMING DRUG RESISTANCE IN PATHOGENS

COMPOUNDS BASED ON TRIS(1-ALKYLINDOL-3-YL)METHAN FOR OVERCOMING DRUG RESISTANCE IN PATHOGENS

Trls(1-alkylindol-3-yl)methylium salts that are trls(1-alkylindol-3-yl)methan derivatives with high antibacterial and antifungal activity were obtained through chemical synthesis. These salts were practically not inferior to levolloxacin in their activity against Grampositive bacteria and were almos...

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Bibliographic Details
Main Authors: A. S. Trenin, S. N. Lavrenov, E. P. Mirchink, E. B. Isakova, O. P. Bychkova, A. Y. Simonov, S. A. Lakatosh, E. A. Tsvigun
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
Subjects:
antibacterial and antifungal antibiotics
tris(1-alkylindol-3-yl)methan derivatives
tris(1-alkylindol-3-yl)methylium salts
turbomycin a analogues
antimicrobial activity in vitro and in vivo
multi drug resistance
staphylococcal and candida sepsis models in mice
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/3
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