JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors

JAK-STAT-activated, fratricide-resistant CAR-T cells targeting membrane-bound TNF effectively treat AML and solid tumors

Background While chimeric antigen receptor (CAR)-T cell therapy exhibits a robust therapeutic efficacy against B-cell malignancies and multiple myeloma, its efficacy and safety have not been established for acute myeloid leukemia (AML) and solid tumors due to the paucity of established target antige...

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Main Authors: Yang Li, Taeko Hayakawa, Shinsuke Iida, Toshiaki Yoshikawa, Yusuke Ito, Satoshi Inoue, Yuichi Ishikawa, Takahiro Nakashima, Tetsuya Matsukawa, Hitoshi Kiyoi, Yuki Kagoya, Hitomi Kasuya, Haosong Zhang, Tsunenori Ouchida
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011067.full
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https://jitc.bmj.com/content/13/7/e011067.full

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