Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension

Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension

BackgroundPulmonary arterial hypertension (PAH) is a severe disease marked by the remodeling of arteries due to the abnormal growth of vascular cells, including pulmonary arterial smooth muscle cells (PASMCs). The insulin receptor substrate-1 (IRS-1) plays a crucial role in the insulin signaling pat...

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Bibliographic Details
Main Authors: Gufeng Gao, Ai Chen, Yan Yan, Mohammad Ismail Hajary Sagor, Weijun Lin, Huakan Lin, Guili Lian, Liangdi Xie, Li Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
pulmonary arterial hypertension
pulmonary arterial smooth muscle cells
insulin receptor substrate 1
cell proliferation
migration
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1543319/full
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https://www.frontiersin.org/articles/10.3389/fcvm.2025.1543319/full

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