High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils

High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils

High-grade serious ovarian cancer (HGSOC) is an aggressive malignancy that remains refractory to current immunotherapies. While advanced stage disease has been extensively studied, the cellular and molecular mechanisms that promote early immune escape in HGSOC remain largely unexplored. Here, we rep...

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Bibliographic Details
Main Authors: Alexander Emmanuelli, Camilla Salvagno, Sung-Min Hwang, Deepika Awasthi, Tito A. Sandoval, Chang-Suk Chae, Jin-Gyu Cheong, Chen Tan, Takao Iwawaki, Juan R. Cubillos-Ruiz
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
ER stress
immunotherapy
IRE1
neutrophils
ovarian cancer
PD-1 blockade
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2411070
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2411070

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