Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics

Computationally unmasking each fatty acyl C=C position in complex lipids by routine LC-MS/MS lipidomics

Abstract Identifying carbon-carbon double bond (C=C) positions in complex lipids is essential for elucidating physiological and pathological processes. Currently, this is impossible in high-throughput analyses of native lipids without specialized instrumentation that compromises ion yields. Here, we...

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Main Authors: Leonida M. Lamp, Gosia M. Murawska, Joseph P. Argus, Aaron M. Armando, Radu A. Talmazan, Marlene Pühringer, Evelyn Rampler, Oswald Quehenberger, Edward A. Dennis, Jürgen Hartler
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61911-x
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https://doi.org/10.1038/s41467-025-61911-x

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