Mutant p53 induces SH3BGRL expression to promote cell engulfment

Mutant p53 induces SH3BGRL expression to promote cell engulfment

Abstract Previously, we identified that mutant p53 expression in cancer cells promotes engulfment of neighbouring cancer cells to form cell-in-cell (CIC) structures. This process gave mutant p53 cells an advantage in tumour formation in mouse xenograft experiments. TP53 can be found mutated at nearl...

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Main Authors: Lobsang Dolma, Mary I. Patterson, Antonia Banyard, Callum Hall, Steven Bell, Wolfgang Breitwieser, Sudhakar Sahoo, John Weightman, Maria Pazos Gil, Garry Ashton, Caron Behan, Nicola Fullard, Lewis D. Williams, Patricia AJ. Muller
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02582-x
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https://doi.org/10.1038/s41420-025-02582-x

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