Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model

Establishing translational performance standards for TB therapy using rifampicin-based regimens in a male and female high-burden murine model

Abstract Background Establishing efficacy benchmarks in preclinical tuberculosis (TB) models is essential for optimizing and prioritizing therapeutic regimens. However, standardized classification methods for comparing high-performing regimens are currently lacking. This study defines a quantitative...

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Bibliographic Details
Main Authors: Jason E. Cummings, Lisa Woolhiser, Barbara Graham, Gregory T. Robertson, M. Nurul Islam, Richard A. Slayden
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
High-burden aerosol balb/C model
High burden
Tuberculosis
Online Access:https://doi.org/10.1186/s12866-025-04196-w
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https://doi.org/10.1186/s12866-025-04196-w

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